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TargetTranscriptional regulator ERG
LigandBDBM50417415
Substrate/Competitorn/a
Meas. Tech.ChEMBL_686392 (CHEMBL1293148)
Ki 7943.28±n/a nM
Citation Bromidge, SMArban, RBertani, BBorriello, MCapelli, AMDi-Fabio, RFaedo, SGianotti, MGordon, LJGranci, EPasquarello, ASpada, SKWorby, AZonzini, LZucchelli, V 5-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}-2(1H)-quinolinones and 3,4-dihydro-2(1H)-quinolinones: dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors. Part 3. Bioorg Med Chem Lett20:7092-6 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Transcriptional regulator ERG
Name:Transcriptional regulator ERG
Synonyms:ERG | ERG_HUMAN | Transforming protein ERG
Type:PROTEIN
Mol. Mass.:54615.84
Organism:Homo sapiens (Human)
Description:ChEMBL_1335569
Residue:486
Sequence:
MIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQ
QDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHM
PPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTK
DDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPN
TSVYPEATQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPY
QILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGE
RKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPS
DLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPS
HLGTYY
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  Blast E-value cutoff:
BDBM50417415
n/a
NameBDBM50417415
Synonyms:CHEMBL1289277
TypeSmall organic molecule
Emp. Form.C28H32N4O
Mol. Mass.440.5799
SMILESC[C@@H]1CN(CCN1CCc1c(C)ccc2n(C)c(=O)ccc12)c1cccc2nc(C)ccc12 |r|
Structure
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