| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M5 |
|---|
| Ligand | BDBM50296345 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_687869 (CHEMBL1291433) |
|---|
| IC50 | 0.1±n/a nM |
|---|
| Citation |  Stocks, MJ; Alcaraz, L; Bailey, A; Bowers, K; Donald, D; Edwards, H; Hunt, F; Kindon, N; Pairaudeau, G; Theaker, J; Warner, DJ The discovery of new spirocyclic muscarinic M3 antagonists. Bioorg Med Chem Lett20:7458-61 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Muscarinic acetylcholine receptor M5 |
|---|
| Name: | Muscarinic acetylcholine receptor M5 |
|---|
| Synonyms: | ACM5_HUMAN | CHRM5 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 60102.35 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1517990 |
|---|
| Residue: | 532 |
|---|
| Sequence: | MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQ
LKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMN
LLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPL
DECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAE
KRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQL
TTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPN
YLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNP
NPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLG
YWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
|
|
|
|---|
| BDBM50296345 |
|---|
| n/a |
|---|
| Name | BDBM50296345 |
|---|
| Synonyms: | (1R,2R,4S,5R,7S)-7-(2-hydroxy-2,2-di-thiophen-2-yl-acetoxy)-9,9-dimethyl-3-oxa-9-azonia-tricyclo[3.3.1.0*2,4*]nonane bromide | CHEMBL258622 | Tiotropium Bromide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H22NO4S2 |
|---|
| Mol. Mass. | 392.512 |
|---|
| SMILES | C[N+]1(C)[C@@H]2C[C@H](C[C@@H]1[C@@H]1O[C@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 |TLB:11:5:1:8.10| |
|---|
| Structure | 
|
|---|
Search and Browse
