Reaction Details | |||
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Target | Vitamin D3 receptor | ||
Ligand | BDBM50417519 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_695918 (CHEMBL1641105) | ||
Ki | 0.08±n/a nM | ||
Citation | Grzywacz, P; Chiellini, G; Plum, LA; Clagett-Dame, M; DeLuca, HF Removal of the 26-methyl group from 19-nor-1a,25-dihydroxyvitamin D3 markedly reduces in vivo calcemic activity without altering in vitro VDR binding, HL-60 cell differentiation, and transcription. J Med Chem53:8642-9 (2010) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Vitamin D3 receptor | |||
Name: | Vitamin D3 receptor | ||
Synonyms: | Nr1i1 | VDR_RAT | Vdr | Vitamin D receptor | ||
Type: | PROTEIN | ||
Mol. Mass.: | 47811.07 | ||
Organism: | Rattus norvegicus | ||
Description: | ChEMBL_1505946 | ||
Residue: | 423 | ||
Sequence: |
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BDBM50417519 | |||
n/a | |||
Name | BDBM50417519 | ||
Synonyms: | CHEMBL1630759 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H44O3 | ||
Mol. Mass. | 404.6258 | ||
SMILES | C[C@@H](O)CCC[C@H](C)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C1C[C@@H](O)C(C)[C@H](O)C1 |r,wU:22.24,11.10,16.18,8.7,6.6,1.1,wD:26.28,(1.96,-41.79,;.6,-42.52,;.6,-44.06,;-.7,-41.71,;-2.06,-42.44,;-3.37,-41.62,;-4.73,-42.35,;-6.07,-41.6,;-4.71,-43.89,;-3.82,-45.14,;-4.73,-46.37,;-6.18,-45.89,;-7.5,-46.66,;-8.85,-45.89,;-8.84,-44.35,;-7.5,-43.58,;-6.17,-44.36,;-6.18,-42.82,;-7.5,-48.2,;-8.84,-48.97,;-8.84,-50.51,;-7.51,-51.29,;-7.51,-52.83,;-6.17,-53.6,;-8.84,-53.59,;-8.84,-55.13,;-10.17,-52.83,;-11.51,-53.6,;-10.17,-51.29,)| | ||
Structure |