Reaction Details |
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Target | Protein kinase C epsilon type |
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Ligand | BDBM50417843 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_716671 (CHEMBL1670496) |
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IC50 | 398.11±n/a nM |
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Citation | Ray, P; Wright, J; Adam, J; Boucharens, S; Black, D; Brown, AR; Epemolu, O; Fletcher, D; Huggett, M; Jones, P; Laats, S; Lyons, A; de Man, J; Morphy, R; Sherborne, B; Sherry, L; Straten, Nv; Westwood, P; York, M Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors. Bioorg Med Chem Lett21:1084-8 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Protein kinase C epsilon type |
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Name: | Protein kinase C epsilon type |
Synonyms: | KPCE_HUMAN | PKC epsilon | PKCE | PRKCE | Protein kinase C epsilon | Protein kinase C epsilon type | Protein kinase C, PKC; classical/novel | Protein kinase C, epsilon | nPKC-epsilon |
Type: | Enzyme |
Mol. Mass.: | 83680.45 |
Organism: | Homo sapiens (Human) |
Description: | The recombinant human PKC enzymes were
produced using a baculovirus expression system in SF9 cells |
Residue: | 737 |
Sequence: | MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIALNVDDSRIGQTATKQKT
NSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGSRHFEDWIDLE
PEGRVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQP
TYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDQVGSQRFSVN
MPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIA
KVLADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPTSPCDQEIKELE
NNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFG
KVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKD
RLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILL
DAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEM
MAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGED
AIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQI
NQEEFKGFSYFGEDLMP
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BDBM50417843 |
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n/a |
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Name | BDBM50417843 |
Synonyms: | CHEMBL1667967 |
Type | Small organic molecule |
Emp. Form. | C14H16N2O2 |
Mol. Mass. | 244.289 |
SMILES | O=c1[nH]ccc2cc(O[C@H]3CCCNC3)ccc12 |r| |
Structure |
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