| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP-dependent protein kinase catalytic subunit PRKX |
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| Ligand | BDBM50417844 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_716673 (CHEMBL1670498) |
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| IC50 | 6309.57±n/a nM |
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| Citation |  Ray, P; Wright, J; Adam, J; Boucharens, S; Black, D; Brown, AR; Epemolu, O; Fletcher, D; Huggett, M; Jones, P; Laats, S; Lyons, A; de Man, J; Morphy, R; Sherborne, B; Sherry, L; Straten, Nv; Westwood, P; York, M Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors. Bioorg Med Chem Lett21:1084-8 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| cAMP-dependent protein kinase catalytic subunit PRKX |
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| Name: | cAMP-dependent protein kinase catalytic subunit PRKX |
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| Synonyms: | PKX1 | PRKX | PRKX_HUMAN | Serine/threonine-protein kinase PRKX |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 40897.91 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_4826948 |
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| Residue: | 358 |
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| Sequence: | MEAPGLAQAAAAESDSRKVAEETPDGAPALCPSPEALSPEPPVYSLQDFDTLATVGTGTF
GRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRLFWTWHDER
FLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILL
DRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSG
FPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHH
RWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVPQKDLEIFKNF
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| BDBM50417844 |
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| n/a |
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| Name | BDBM50417844 |
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| Synonyms: | CHEMBL1667963 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H18N4O2S |
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| Mol. Mass. | 306.383 |
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| SMILES | Nc1nccc2c(cccc12)S(=O)(=O)N1CCCNCC1 |
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| Structure | 
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