| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 2E1 |
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| Ligand | BDBM50027781 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_774177 (CHEMBL1908272) |
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| Ki | 188000±n/a nM |
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| Citation |  Fontana, E; Dansette, PM; Poli, SM Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Curr Drug Metab6:413-54 (2005) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 2E1 |
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| Name: | Cytochrome P450 2E1 |
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| Synonyms: | 4-nitrophenol 2-hydroxylase | CP2E1_RAT | CYPIIE1 | Cyp2e | Cyp2e-1 | Cyp2e1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 56637.32 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | CYP2E1 prepared from rat liver microsomes was used in enzyme assays. |
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| Residue: | 493 |
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| Sequence: | MAVLGITIALLVWVATLLVISIWKQIYNSWNLPPGPFPLPILGNIFQLDLKDIPKSFTKL
AKRFGPVFTLHLGSRRIVVLHGYKAVKEVLLNHKNEFSGRGDIPVFQEYKNKGIIFNNGP
TWKDVRRFSLSILRDWGMGKQGNEARIQREAQFLVEELKKTKGQPFDPTFLIGCAPCNVI
ADILFNKRFDYNDKKCLRLMSLFNENFYLLSTPWIQLYNNFADYLRYLPGSHRKIMKNVS
EIKQYTLEKAKEHLQSLDINCARDVTDCLLIEMEKEKHSQEPMYTMENVSVTLADLFFAG
TETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRVPAVRDRLDMPYMDAVVHEIQRF
INLVPSNLPHEATRDTVFQGYVIPKGTVVIPTLDSLLYDSHEFPDPEKFKPEHFLNENGK
FKYSDYFKAFSAGKRVCVGEGLARMELFLLLSAILQHFNLKSLVDPKDIDLSPVTVGFGS
IPPQFKLCVIPRS
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| BDBM50027781 |
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| n/a |
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| Name | BDBM50027781 |
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| Synonyms: | Diallylsulfone |
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| Type | Small organic molecule |
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| Emp. Form. | C6H10O2S |
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| Mol. Mass. | 146.207 |
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| SMILES | C=CCS(=O)(=O)CC=C |
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| Structure | 
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