| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Inhibitor of nuclear factor kappa-B kinase subunit alpha |
|---|
| Ligand | BDBM50418165 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_741020 (CHEMBL1764206) |
|---|
| IC50 | 1995.26±n/a nM |
|---|
| Citation |  Miller, DD; Bamborough, P; Christopher, JA; Baldwin, IR; Champigny, AC; Cutler, GJ; Kerns, JK; Longstaff, T; Mellor, GW; Morey, JV; Morse, MA; Nie, H; Rumsey, WL; Taggart, JJ 3,5-Disubstituted-indole-7-carboxamides: the discovery of a novel series of potent, selective inhibitors of IKK-ß. Bioorg Med Chem Lett21:2255-8 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Inhibitor of nuclear factor kappa-B kinase subunit alpha |
|---|
| Name: | Inhibitor of nuclear factor kappa-B kinase subunit alpha |
|---|
| Synonyms: | CHUK | Conserved helix-loop-helix ubiquitous kinase | I-kappa-B kinase 1 | I-kappa-B kinase alpha | IKK-A | IKK-alpha | IKK1 | IKK2/IKK1 | IKKA | IKKA_HUMAN | IkBKA | IkappaB kinase | Inhibitor of NF-kappa-B kinase alpha/beta | NFKBIKA | Nuclear factor NF-kappa-B inhibitor kinase alpha | TCF-16 | TCF16 | Transcription factor 16 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 84642.21 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_327453 |
|---|
| Residue: | 745 |
|---|
| Sequence: | MERPPGLRPGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCH
EIQIMKKLNHANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQ
ILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTS
FVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPK
CIFACEEMSGEVRFSSHLPQPNSLCSLVVEPMENWLQLMLNWDPQQRGGPVDLTLKQPRC
FVLMDHILNLKIVHILNMTSAKIISFLLPPDESLHSLQSRIERETGINTGSQELLSETGI
SLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQDSKIQLPI
IQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTLISASQQLKAKL
EFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYAEVGVIGYLEDQIMSLHAE
IMELQKSPYGRRQGDLMESLEQRAIDLYKQLKHRPSDHSYSDSTEMVKIIVHTVQSQDRV
LKELFGHLSKLLGCKQKIIDLLPKVEVALSNIKEADNTVMFMQGKRQKEIWHLLKIACTQ
SSARSLVGSSLEGAVTPQTSAWLPPTSAEHDHSLSCVVTPQDGETSAQMIEENLNCLGHL
STIIHEANEEQGNSMMNLDWSWLTE
|
|
|
|---|
| BDBM50418165 |
|---|
| n/a |
|---|
| Name | BDBM50418165 |
|---|
| Synonyms: | CHEMBL1761512 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H27N3O3S |
|---|
| Mol. Mass. | 425.544 |
|---|
| SMILES | CCCS(=O)(=O)N1CCC(CC1)c1c[nH]c2c(cc(cc12)-c1ccccc1)C(N)=O |
|---|
| Structure | 
|
|---|
Search and Browse
