Reaction Details |
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Target | Inhibitor of nuclear factor kappa-B kinase subunit alpha |
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Ligand | BDBM50418179 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_741020 (CHEMBL1764206) |
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IC50 | 15848.93±n/a nM |
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Citation | Miller, DD; Bamborough, P; Christopher, JA; Baldwin, IR; Champigny, AC; Cutler, GJ; Kerns, JK; Longstaff, T; Mellor, GW; Morey, JV; Morse, MA; Nie, H; Rumsey, WL; Taggart, JJ 3,5-Disubstituted-indole-7-carboxamides: the discovery of a novel series of potent, selective inhibitors of IKK-ß. Bioorg Med Chem Lett21:2255-8 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Inhibitor of nuclear factor kappa-B kinase subunit alpha |
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Name: | Inhibitor of nuclear factor kappa-B kinase subunit alpha |
Synonyms: | CHUK | Conserved helix-loop-helix ubiquitous kinase | I-kappa-B kinase 1 | I-kappa-B kinase alpha | IKK-A | IKK-alpha | IKK1 | IKK2/IKK1 | IKKA | IKKA_HUMAN | IkBKA | IkappaB kinase | Inhibitor of NF-kappa-B kinase alpha/beta | NFKBIKA | Nuclear factor NF-kappa-B inhibitor kinase alpha | TCF-16 | TCF16 | Transcription factor 16 |
Type: | PROTEIN |
Mol. Mass.: | 84642.21 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_327453 |
Residue: | 745 |
Sequence: | MERPPGLRPGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCH
EIQIMKKLNHANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQ
ILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTS
FVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPK
CIFACEEMSGEVRFSSHLPQPNSLCSLVVEPMENWLQLMLNWDPQQRGGPVDLTLKQPRC
FVLMDHILNLKIVHILNMTSAKIISFLLPPDESLHSLQSRIERETGINTGSQELLSETGI
SLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQDSKIQLPI
IQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTLISASQQLKAKL
EFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYAEVGVIGYLEDQIMSLHAE
IMELQKSPYGRRQGDLMESLEQRAIDLYKQLKHRPSDHSYSDSTEMVKIIVHTVQSQDRV
LKELFGHLSKLLGCKQKIIDLLPKVEVALSNIKEADNTVMFMQGKRQKEIWHLLKIACTQ
SSARSLVGSSLEGAVTPQTSAWLPPTSAEHDHSLSCVVTPQDGETSAQMIEENLNCLGHL
STIIHEANEEQGNSMMNLDWSWLTE
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BDBM50418179 |
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n/a |
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Name | BDBM50418179 |
Synonyms: | CHEMBL1761506 |
Type | Small organic molecule |
Emp. Form. | C16H14N2O2 |
Mol. Mass. | 266.2946 |
SMILES | NC(=O)c1cc(cc2cc[nH]c12)-c1ccc(CO)cc1 |
Structure |
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