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TargetVasopressin V1a receptor
LigandBDBM50418397
Substrate/Competitorn/a
Meas. Tech.ChEMBL_746762
Ki 2.95±n/a nM
Citation Napier SWishart GArbuckle WBaker JBarn DBingham MBrown AByford AClaxton CCraighead MBuchanan KFielding LGibson LGoodwin RGoutcher SIrving NMacSweeney CMilne RMort CPresland JSloan HThomson FTurnbull ZYoung T The discovery of novel 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamides as vasopressin V1A receptor antagonists. Bioorg Med Chem Lett 21:3163-7 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Vasopressin V1a receptor
Name:Vasopressin V1a receptor
Synonyms:AVPR V1a | AVPR1 | AVPR1A | Antidiuretic hormone receptor 1a | V1aR | VASOPRESSIN V1A | Vascular/hepatic-type arginine vasopressin receptor | Vasopressin V1 receptor
Type:Receptor
Mol. Mass.:46820.18
Organism:Homo sapiens (Human)
Description:P37288
Residue:418
Sequence:
MRLSAGPDAGPSGNSSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAV
TFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGP
DWLCRVVKHLQVFGMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFV
LSTPQYFVFSMIEVNNVTKARDCWATFIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFIC
YNIWCNVRGKTASRQSKGAEQAGVAFQKGFLLAPCVSSVKSISRAKIRTVKMTFVIVTAY
IVCWAPFFIIQMWSVWDPMSVWTESENPTITITALLGSLNSCCNPWIYMFFSGHLLQDCV
QSFPCCQNMKEKFNKEDTDSMSRRQTFYSNNRSPTNSTGMWKDSPKSSKSIKFIPVST
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  Blast E-value cutoff:
BDBM50418397
n/a
NameBDBM50418397
Synonyms:CHEMBL1773857
TypeSmall organic molecule
Emp. Form.C34H45ClN4O4S
Mol. Mass.641.264
SMILESCOc1cc(C)c(c(C)c1C)S(=O)(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N(CCCN1CCN(C)CC1)Cc1ccccc1 |r|
Structure
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