Reaction Details |
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Target | C-C chemokine receptor type 5 |
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Ligand | BDBM50418489 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_751710 (CHEMBL1788061) |
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IC50 | 15.85±n/a nM |
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Citation | Kazmierski, WM; Anderson, DL; Aquino, C; Chauder, BA; Duan, M; Ferris, R; Kenakin, T; Koble, CS; Lang, DG; McIntyre, MS; Peckham, J; Watson, C; Wheelan, P; Spaltenstein, A; Wire, MB; Svolto, A; Youngman, M Novel 4,4-disubstituted piperidine-based C-C chemokine receptor-5 inhibitors with high potency against human immunodeficiency virus-1 and an improved human ether-a-go-go related gene (hERG) profile. J Med Chem54:3756-67 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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C-C chemokine receptor type 5 |
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Name: | C-C chemokine receptor type 5 |
Synonyms: | C-C CKR-5 | C-C chemokine receptor type 5 | CC-CKR-5 | CCR-5 | CCR5 | CCR5/mu opioid receptor complex | CCR5_HUMAN | CD_antigen=CD195 | CHEMR13 | CMKBR5 | HIV-1 fusion coreceptor |
Type: | Enzyme |
Mol. Mass.: | 40540.21 |
Organism: | Homo sapiens (Human) |
Description: | P51681 |
Residue: | 352 |
Sequence: | MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKR
LKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFII
LLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSS
HFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTI
MIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFV
GEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
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BDBM50418489 |
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n/a |
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Name | BDBM50418489 |
Synonyms: | CHEMBL1784384 |
Type | Small organic molecule |
Emp. Form. | C35H40N4O |
Mol. Mass. | 532.7183 |
SMILES | Cc1nc2ccccc2n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CCC1(CCN(CC1)C(=O)c1ccccc1)c1ccccc1 |r,THB:18:17:11.10.16:13.14| |
Structure |
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