| Reaction Details |
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 | Report a problem with these data |
| Target | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial |
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| Ligand | BDBM50190543 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_758853 (CHEMBL1810457) |
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| Ki | 46000±n/a nM |
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| Citation |  Recio, E; Musso-Buendía, A; Vidal, AE; Ruda, GF; Kasinathan, G; Nguyen, C; Ruiz-Pérez, LM; Gilbert, IH; González-Pacanowska, D Site-directed mutagenesis provides insights into the selective binding of trityl derivatives to Plasmodium falciparum dUTPase. Eur J Med Chem46:3309-14 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial |
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| Name: | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial |
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| Synonyms: | DUT | DUT_HUMAN | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) | Deoxyuridine triphosphatase (dUTPase) | dUTP pyrophosphatase |
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| Type: | Enzyme |
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| Mol. Mass.: | 26574.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P33316 |
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| Residue: | 252 |
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| Sequence: | MTPLCPRPALCYHFLTSLLRSAMQNARGARQRAEAAVLSGPGPPLGRAAQHGIPRPLSSA
GRLSQGCRGASTVGAAGWKGELPKAGGSPAPGPETPAISPSKRARPAEVGGMQLRFARLS
EHATAPTRGSARAAGYDLYSAYDYTIPPMEKAVVKTDIQIALPSGCYGRVAPRSGLAAKH
FIDVGAGVIDEDYRGNVGVVLFNFGKEKFEVKKGDRIAQLICERIFYPEIEEVQALDDTE
RGSGGFGSTGKN
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| BDBM50190543 |
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| n/a |
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| Name | BDBM50190543 |
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| Synonyms: | 1-((2R,4S,5R)-4-hydroxy-5-((tritylamino)methyl)-tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione | 1-((2R,4S,5R)-4-hydroxy-5-((tritylamino)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione | CHEMBL377582 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H27N3O4 |
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| Mol. Mass. | 469.5317 |
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| SMILES | O[C@H]1C[C@@H](O[C@@H]1CNC(c1ccccc1)(c1ccccc1)c1ccccc1)n1ccc(=O)[nH]c1=O |r| |
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| Structure | 
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