| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-1 adrenergic receptor |
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| Ligand | BDBM50418950 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_759387 (CHEMBL1810625) |
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| IC50 | 100±n/a nM |
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| Citation |  Connolly, S; Alcaraz, L; Bailey, A; Cadogan, E; Christie, J; Cook, AR; Fisher, AJ; Hill, S; Humphries, A; Ingall, AH; Kane, Z; Paine, S; Pairaudeau, G; Stocks, MJ; Young, A Design-driven LO: the discovery of new ultra long acting dibasicß2-adrenoceptor agonists. Bioorg Med Chem Lett21:4612-6 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-1 adrenergic receptor |
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| Name: | Beta-1 adrenergic receptor |
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| Synonyms: | ADRB1 | ADRB1R | ADRB1_HUMAN | B1AR | Beta-1 adrenoceptor | adrenergic Beta1 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 51338.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08588 |
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| Residue: | 477 |
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| Sequence: | MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAG
MGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVV
WGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVC
TVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIM
AFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAP
LANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFV
FFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAARRRHATHGDRPRASGCLARPGP
PPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
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| BDBM50418950 |
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| n/a |
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| Name | BDBM50418950 |
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| Synonyms: | CHEMBL1807832 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H28ClN3O4S |
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| Mol. Mass. | 465.993 |
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| SMILES | O[C@@H](CNCCOCCCNCCc1cccc(Cl)c1)c1ccc(O)c2[nH]c(=O)sc12 |r| |
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| Structure | 
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