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TargetHistamine H4 receptor
LigandBDBM50326297
Substrate/Competitorn/a
Meas. Tech.ChEMBL_766543
Ki 100±n/a nM
Citation Verheij MHde Graaf Cde Kloe GENijmeijer SVischer HFSmits RAZuiderveld OPHulscher SSilvestri LThompson AJvan Muijlwijk-Koezen JELummis SCLeurs Rde Esch IJ Fragment library screening reveals remarkable similarities between the G protein-coupled receptor histamine H4 and the ion channel serotonin 5-HT3A. Bioorg Med Chem Lett 21:5460-4 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histamine H4 receptor
Name:Histamine H4 receptor
Synonyms:AXOR35 | G-protein coupled receptor 105 | GPRv53 | HH4R | HISTAMINE H4 | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:44517.02
Organism:Homo sapiens (Human)
Description:Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF
LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA
STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR
LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL
CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
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BDBM50326297
n/a
NameBDBM50326297
Synonyms:3-((1H-imidazol-4-yl)methyl)pyridine | 3-(3H-Imidazol-4-ylmethyl)-pyridine | CHEMBL78838
TypeSmall organic molecule
Emp. Form.C9H9N3
Mol. Mass.159.1879
SMILESC(c1cnc[nH]1)c1cccnc1
Structure
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