| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H4 receptor |
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| Ligand | BDBM50326297 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_766543 |
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| Ki | 100±n/a nM |
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| Citation |  Verheij MH; de Graaf C; de Kloe GE; Nijmeijer S; Vischer HF; Smits RA; Zuiderveld OP; Hulscher S; Silvestri L; Thompson AJ; van Muijlwijk-Koezen JE; Lummis SC; Leurs R; de Esch IJ Fragment library screening reveals remarkable similarities between the G protein-coupled receptor histamine H4 and the ion channel serotonin 5-HT3A. Bioorg Med Chem Lett 21:5460-4 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H4 receptor |
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| Name: | Histamine H4 receptor |
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| Synonyms: | AXOR35 | G-protein coupled receptor 105 | GPRv53 | HH4R | HISTAMINE H4 | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44517.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Binding assays were using CHO cells stably expressing hH4R receptors. |
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| Residue: | 390 |
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| Sequence: | MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF
LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA
STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR
LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL
CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
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| BDBM50326297 |
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| n/a |
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| Name | BDBM50326297 |
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| Synonyms: | 3-((1H-imidazol-4-yl)methyl)pyridine | 3-(3H-Imidazol-4-ylmethyl)-pyridine | CHEMBL78838 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H9N3 |
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| Mol. Mass. | 159.1879 |
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| SMILES | C(c1cnc[nH]1)c1cccnc1 |
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| Structure | 
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