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TargetHistamine H4 receptor
LigandBDBM26390
Substrate/Competitorn/a
Meas. Tech.ChEMBL_766543
Ki 6.31±n/a nM
Citation Verheij MHde Graaf Cde Kloe GENijmeijer SVischer HFSmits RAZuiderveld OPHulscher SSilvestri LThompson AJvan Muijlwijk-Koezen JELummis SCLeurs Rde Esch IJ Fragment library screening reveals remarkable similarities between the G protein-coupled receptor histamine H4 and the ion channel serotonin 5-HT3A. Bioorg Med Chem Lett 21:5460-4 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histamine H4 receptor
Name:Histamine H4 receptor
Synonyms:AXOR35 | G-protein coupled receptor 105 | GPRv53 | HH4R | HISTAMINE H4 | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:44517.02
Organism:Homo sapiens (Human)
Description:Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF
LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA
STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR
LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL
CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
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  Blast E-value cutoff:
BDBM26390
n/a
NameBDBM26390
Synonyms:4-(4-methylpiperazin-1-yl)-6-phenylpyrimidin-2-amine | 6-aryl-2-aminopyrimidine, 3
TypeSmall organic molecule
Emp. Form.C15H19N5
Mol. Mass.269.3449
SMILESCN1CCN(CC1)c1cc(nc(N)n1)-c1ccccc1
Structure
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