| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H4 receptor |
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| Ligand | BDBM50419049 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_766544 (CHEMBL1827025) |
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| Ki | 630.96±n/a nM |
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| Citation |  Verheij, MH; de Graaf, C; de Kloe, GE; Nijmeijer, S; Vischer, HF; Smits, RA; Zuiderveld, OP; Hulscher, S; Silvestri, L; Thompson, AJ; van Muijlwijk-Koezen, JE; Lummis, SC; Leurs, R; de Esch, IJ Fragment library screening reveals remarkable similarities between the G protein-coupled receptor histamine H4 and the ion channel serotonin 5-HT3A. Bioorg Med Chem Lett21:5460-4 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H4 receptor |
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| Name: | Histamine H4 receptor |
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| Synonyms: | AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44517.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Binding assays were using CHO cells stably expressing hH4R receptors. |
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| Residue: | 390 |
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| Sequence: | MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF
LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA
STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR
LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL
CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
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| BDBM50419049 |
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| n/a |
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| Name | BDBM50419049 |
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| Synonyms: | CHEMBL1824228 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H16N2 |
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| Mol. Mass. | 164.2474 |
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| SMILES | C(C1CCCCC1)c1cnc[nH]1 |
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| Structure | 
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