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TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
LigandBDBM50419075
Substrate/Competitorn/a
Meas. Tech.ChEMBL_767270 (CHEMBL1825382)
IC50 630.96±n/a nM
Citation McClure, KJMaher, MWu, NChaplan, SREckert, WALee, DHWickenden, ADHermann, MAllison, BHawryluk, NBreitenbucher, JGGrice, CA Discovery of a novel series of selective HCN1 blockers. Bioorg Med Chem Lett21:5197-201 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Name:Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Synonyms:BCNG-1 | BCNG1 | Brain cyclic nucleotide-gated channel 1 | HCN1 | HCN1_HUMAN
Type:PROTEIN
Mol. Mass.:98811.53
Organism:Homo sapiens (Human)
Description:ChEMBL_767270
Residue:890
Sequence:
MEGGGKPNSSSNSRDDGNSVFPAKASATGAGPAAAEKRLGTPPGGGGAGAKEHGNSVCFK
VDGGGGGGGGGGGGEEPAGGFEDAEGPRRQYGFMQRQFTSMLQPGVNKFSLRMFGSQKAV
EKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNV
ASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVE
KGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFN
LIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIG
YGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSF
HKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANAD
PNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGE
ICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSI
LLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQAIAPINYPQMTTLNSTSSTTTPTSRM
RTQSPPVYTATSLSHSNLHSPSPSTQTPQPSAILSPCSYTTAVCSPPVQSPLAARTFHYA
SPTASQLSLMQQQPQQQVQQSQPPQTQPQQPSPQPQTPGSSTPKNEVHKSTQALHNTNLT
REVRPLSASQPSLPHEVSTLISRPHPTVGESLASIPQPVTAVPGTGLQAGGRSTVPQRVT
LFRQMSSGAIPPNRGVPPAPPPPAAALPRESSSVLNTDPDAEKPRFASNL
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  Blast E-value cutoff:
BDBM50419075
n/a
NameBDBM50419075
Synonyms:CHEMBL1823888
TypeSmall organic molecule
Emp. Form.C27H38N4O2
Mol. Mass.450.6162
SMILESCOc1ccccc1C(=O)NCC1(CCN(CC1)c1ccccc1)N1CCN(CC1)C(C)C
Structure
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