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TargetAurora kinase B
LigandBDBM50419265
Substrate/Competitorn/a
Meas. Tech.ChEMBL_772964 (CHEMBL1838852)
IC50 1259±n/a nM
Citation Liddle, JAtkinson, FLBarker, MDCarter, PSCurtis, NRDavis, RPDouault, CDickson, MCElwes, DGarton, NSGray, MHayhow, TGHobbs, CIJones, ELeach, SLeavens, KLewis, HDMcCleary, SNeu, MPatel, VKPreston, AGRamirez-Molina, CShipley, TJSkone, PASmithers, NSomers, DOWalker, ALWatson, RJWeingarten, GG Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor. Bioorg Med Chem Lett21:6188-94 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Aurora kinase B
Name:Aurora kinase B
Synonyms:AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:Protein
Mol. Mass.:39327.72
Organism:Homo sapiens (Human)
Description:Q96GD4
Residue:344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50419265
n/a
NameBDBM50419265
Synonyms:CHEMBL1835069
TypeSmall organic molecule
Emp. Form.C18H22F2N6O
Mol. Mass.376.4037
SMILESCc1cccc(Nc2nc(N[C@@H]3CC(F)(F)CC[C@@H]3N)ncc2C(N)=O)c1 |r|
Structure
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