| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H4 receptor |
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| Ligand | BDBM24226 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_775966 (CHEMBL1912709) |
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| Ki | 7943.28±n/a nM |
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| Citation |  Wagner, E; Wittmann, HJ; Elz, S; Strasser, A Mepyramine-JNJ7777120-hybrid compounds show high affinity to hH(1)R, but low affinity to hH(4)R. Bioorg Med Chem Lett21:6274-80 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H4 receptor |
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| Name: | Histamine H4 receptor |
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| Synonyms: | AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44517.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Binding assays were using CHO cells stably expressing hH4R receptors. |
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| Residue: | 390 |
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| Sequence: | MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF
LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA
STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR
LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL
CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
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| BDBM24226 |
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| n/a |
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| Name | BDBM24226 |
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| Synonyms: | 1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-1,3-benzodiazol-2-amine | ASTEMIZOLE | Astemizole, [O-Methyl-3H] | CHEMBL296419 | Hismanal | Histaminos | [3H]-ASTEMIZOLE | [3H]Astemizole | cid_2247 | med.21724, Compound Astemizole |
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| Type | Radiolabeled ligand |
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| Emp. Form. | C28H31FN4O |
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| Mol. Mass. | 458.5703 |
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| SMILES | COc1ccc(CCN2CCC(CC2)Nc2nc3ccccc3n2Cc2ccc(F)cc2)cc1 |
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| Structure | 
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