Ki Summary

Reaction Details

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Target

fMet-Leu-Phe receptor

Ligand

BDBM50419562

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_796441 (CHEMBL1937756)

IC50

4±n/a nM

Citation

Morley, AD; King, S; Roberts, B; Lever, S; Teobald, B; Fisher, A; Cook, T; Parker, B; Wenlock, M; Phillips, C; Grime, K Lead optimisation of pyrazoles as novel FPR1 antagonists. Bioorg Med Chem Lett22:532-6 (2011) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

fMet-Leu-Phe receptor

Name:

fMet-Leu-Phe receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

38456.14

Organism:

Homo sapiens (Human)

Description:

gi_4503779

Residue:

350

Sequence:

METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVT
TISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIA
LDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNF
SPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPL
RVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPML
YVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK

BDBM50419562

n/a

Name

BDBM50419562

Synonyms:

CHEMBL1934424

Type

Small organic molecule

Emp. Form.

C25H38N4O4S

Mol. Mass.

490.659

SMILES

CO[C@H]1CC[C@H](CC1)n1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c1ccc(C)cc1 |r,wU:5.8,16.17,2.1,(31.27,-8.16,;32.01,-6.81,;31.21,-5.49,;29.67,-5.52,;28.87,-4.21,;29.61,-2.86,;31.15,-2.82,;31.95,-4.13,;29.13,-1.41,;27.66,-.94,;27.66,.6,;26.41,1.51,;29.12,1.08,;29.59,2.55,;31.1,2.88,;28.56,3.69,;29.03,5.16,;27.99,6.3,;30.53,5.48,;31.57,4.34,;31,6.95,;32.01,5.9,;30.03,-.15,;31.57,-.15,;32.33,1.2,;30.99,1.97,;32.33,2.74,;33.88,1.2,;34.64,-.13,;36.18,-.13,;36.95,1.2,;38.49,1.2,;36.18,2.53,;34.64,2.52,)|

Structure