| Reaction Details |
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 | Report a problem with these data |
| Target | Acetylcholine-binding protein |
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| Ligand | BDBM50080818 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_801486 (CHEMBL1948413) |
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| Ki | 630.96±n/a nM |
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| Citation |  Edink, E; Akdemir, A; Jansen, C; van Elk, R; Zuiderveld, O; de Kanter, FJ; van Muijlwijk-Koezen, JE; Smit, AB; Leurs, R; de Esch, IJ Structure-based design, synthesis and structure-activity relationships of dibenzosuberyl- and benzoate-substituted tropines as ligands for acetylcholine-binding protein. Bioorg Med Chem Lett22:1448-54 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acetylcholine-binding protein |
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| Name: | Acetylcholine-binding protein |
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| Synonyms: | ACHP_LYMST | ACh-binding protein | Acetylcholine Binding protein | Acetylcholine-binding protein (AchBP) | Acetylcholine-binding protein (Ls-AchBP) | AchBP |
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| Type: | n/a |
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| Mol. Mass.: | 26055.52 |
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| Organism: | Lymnaea stagnalis |
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| Description: | Soluble acetylcholine receptor |
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| Residue: | 229 |
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| Sequence: | MRRNIFCLACLWIVQACLSLDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEV
NEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQ
LARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTTENSDD
SEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKGRSEIL
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| BDBM50080818 |
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| n/a |
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| Name | BDBM50080818 |
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| Synonyms: | (-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl)-1-phenylethanone | 2-(6-(beta-Hydroxyphenethyl)-1-methyl-2-piperidyl)acetophenone | 2-{(2R,6S)-6-[(2S)-2-hydroxy-2-phenylethyl]-1-methylpiperidin-2-yl}-1-phenylethanone | 8,10-Diphenyllobelionol | CHEMBL122270 | Lobelin | Lobnico | alpha-Lobeline |
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| Type | Small organic molecule |
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| Emp. Form. | C22H27NO2 |
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| Mol. Mass. | 337.4553 |
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| SMILES | CN1[C@H](C[C@H](O)c2ccccc2)CCC[C@@H]1CC(=O)c1ccccc1 |r| |
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| Structure | 
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