| Reaction Details |
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 | Report a problem with these data |
| Target | Broad substrate specificity ATP-binding cassette transporter ABCG2 |
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| Ligand | BDBM4566 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_835940 (CHEMBL2077078) |
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| IC50 | 200±n/a nM |
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| Citation |  Ozvegy-Laczka, C; Hegedus, T; Várady, G; Ujhelly, O; Schuetz, JD; Váradi, A; Kéri, G; Orfi, L; Német, K; Sarkadi, B High-affinity interaction of tyrosine kinase inhibitors with the ABCG2 multidrug transporter. Mol Pharmacol65:1485-95 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Broad substrate specificity ATP-binding cassette transporter ABCG2 |
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| Name: | Broad substrate specificity ATP-binding cassette transporter ABCG2 |
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| Synonyms: | ABCG2 | ABCG2_HUMAN | ABCP | ATP-Binding Cassette Transporter ABCG2 | ATP-binding cassette sub-family G member 2 | ATP-binding cassette transporter (ABCG2) | ATP-binding cassette, sub-family G, member 2 | BCRP | BCRP1 | Breast cancer resistance protein | CDw338 | MXR | Mitoxantrone resistance-associated protein | Placenta-specific ATP-binding cassette transporter | Urate exporter |
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| Type: | Multi-pass membrane protein; monomer or homodimer; disulfide-linked |
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| Mol. Mass.: | 72329.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9UNQ0 |
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| Residue: | 655 |
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| Sequence: | MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVE
KEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCN
SGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGT
QFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIF
SIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIING
DSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKK
ITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDS
TGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLP
MRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLL
MTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGN
NPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKYS
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| BDBM4566 |
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| n/a |
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| Name | BDBM4566 |
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| Synonyms: | 4-anilinoquinazoline deriv. 1 | CHEMBL91867 | N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}but-2-ynamide |
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| Type | Small organic molecule |
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| Emp. Form. | C18H13BrN4O |
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| Mol. Mass. | 381.226 |
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| SMILES | CC#CC(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1 |
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| Structure | 
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