| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Solute carrier organic anion transporter family member 1A4 |
|---|
| Ligand | BDBM50206509 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_836631 (CHEMBL2077473) |
|---|
| Ki | 72900±n/a nM |
|---|
| Citation |  Sugiyama, D; Kusuhara, H; Shitara, Y; Abe, T; Meier, PJ; Sekine, T; Endou, H; Suzuki, H; Sugiyama, Y Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier. J Pharmacol Exp Ther298:316-22 (2001) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Solute carrier organic anion transporter family member 1A4 |
|---|
| Name: | Solute carrier organic anion transporter family member 1A4 |
|---|
| Synonyms: | Brain digoxin carrier protein | Brain-specific organic anion transporter | OATP-B1 | Oatp1a4 | Oatp2 | SO1A4_RAT | Slc21a5 | Slco1a4 | Sodium-independent organic anion-transporting polypeptide 2 | Solute carrier family 21 member 5 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 73261.82 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_836631 |
|---|
| Residue: | 661 |
|---|
| Sequence: | MGKSEKRVATHGVRCFAKIKMFLLALTCAYVSKSLSGTYMNSMLTQIERQFGIPTSIVGL
INGSFEIGNLLLIIFVSYFGTKLHRPIMIGVGCAVMGLGCFLISLPHFLMGQYEYETILP
TSNVSSNSFFCVENRSQTLNPTQDPSECVKEMKSLMWIYVLVGNIIRGIGETPIMPLGIS
YIEDFAKSENSPLYIGILETGMTIGPLIGLLLASSCANIYVDIESVNTDDLTITPTDTRW
VGAWWIGFLVCAGVNILTSFPFFFFPKTLPKEGLQENVDGTENAKEKKHRKKAKEEKRGI
TKDFFVFMKSLSCNPIYMLFILISVLQFNAFINSFTFMPKYLEQQYGKSTAEVVFLMGLY
MLPPICLGYLIGGLIMKKFKVTVKKAAHLAFWLCLSEYLLSFLSYVMTCDNFPVAGLTTS
YEGVQHQLYVENKVLADCNTRCNCSTNTWDPVCGDNGLAYMSACLAGCEKSVGTGTNMVF
QNCSCIQSSGNSSAVLGLCNKGPDCANKLQYFLIIAIFGCFIYSLAGIPGYMVLLRCIKS
EEKSLGVGLHAFCIRILAGIPAPIYFGALIDRTCLHWGTLKCGEPGACRMYDINSFRRLY
LGLPAALRGASFVPAFFILRLTRTFQFPGDIESSKTDHAEMKLTLKESECTEVLRSKVTE
D
|
|
|
|---|
| BDBM50206509 |
|---|
| n/a |
|---|
| Name | BDBM50206509 |
|---|
| Synonyms: | 4-Dipropylsulfamoyl-benzoic acid | 4-Dipropylsulfamoyl-benzoic acid anion | 4-Dipropylsulfamoyl-benzoic acid(probenecid) | Benemid | CHEMBL897 | PROBENECID | Probalan |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C13H19NO4S |
|---|
| Mol. Mass. | 285.359 |
|---|
| SMILES | CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
