| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Solute carrier family 22 member 8 |
|---|
| Ligand | BDBM17638 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_838511 (CHEMBL2078139) |
|---|
| Ki | 5950±n/a nM |
|---|
| Citation |  Takeda, M; Khamdang, S; Narikawa, S; Kimura, H; Hosoyamada, M; Cha, SH; Sekine, T; Endou, H Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther302:666-71 (2002) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Solute carrier family 22 member 8 |
|---|
| Name: | Solute carrier family 22 member 8 |
|---|
| Synonyms: | OAT3 | Organic anion transporter 3 | S22A8_HUMAN | SLC22A8 | hOAT3 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 59870.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1486920 |
|---|
| Residue: | 542 |
|---|
| Sequence: | MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGPW
VLPMGPNGKPERCLRFVHPPNASLPNDTQRAMEPCLDGWVYNSTKDSIVTEWDLVCNSNK
LKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFR
FLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQL
TVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLN
LQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQI
IFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKG
CLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGI
TALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVEKASQRIPLQPHGPGLG
SS
|
|
|
|---|
| BDBM17638 |
|---|
| n/a |
|---|
| Name | BDBM17638 |
|---|
| Synonyms: | 2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetic acid | CHEMBL6 | Indocin | Indomethacin | US11478464, Compound Indomethacin | US11786535, Compound Indomethacin | US9271961, Indomethacin | indometacin |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H16ClNO4 |
|---|
| Mol. Mass. | 357.788 |
|---|
| SMILES | COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(O)=O)c2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
