| Reaction Details |
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 | Report a problem with these data |
| Target | Solute carrier family 22 member 8 |
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| Ligand | BDBM85245 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_838511 (CHEMBL2078139) |
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| Ki | 1200000±n/a nM |
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| Citation |  Takeda, M; Khamdang, S; Narikawa, S; Kimura, H; Hosoyamada, M; Cha, SH; Sekine, T; Endou, H Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther302:666-71 (2002) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Solute carrier family 22 member 8 |
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| Name: | Solute carrier family 22 member 8 |
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| Synonyms: | OAT3 | Organic anion transporter 3 | S22A8_HUMAN | SLC22A8 | hOAT3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59870.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1486920 |
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| Residue: | 542 |
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| Sequence: | MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGPW
VLPMGPNGKPERCLRFVHPPNASLPNDTQRAMEPCLDGWVYNSTKDSIVTEWDLVCNSNK
LKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFR
FLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQL
TVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLN
LQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQI
IFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKG
CLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGI
TALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVEKASQRIPLQPHGPGLG
SS
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| BDBM85245 |
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| n/a |
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| Name | BDBM85245 |
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| Synonyms: | CAS_36322-90-4 | NSC_4856 | Piroxicam |
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| Type | Small organic molecule |
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| Emp. Form. | C15H13N3O4S |
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| Mol. Mass. | 331.346 |
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| SMILES | CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O |t:12| |
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| Structure | 
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