| Reaction Details |
|---|
 | Report a problem with these data |
| Target | ATP-binding cassette sub-family C member 4 |
|---|
| Ligand | BDBM50366524 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_835929 (CHEMBL2077067) |
|---|
| IC50 | 95000±n/a nM |
|---|
| Citation |  Zelcer, N; Reid, G; Wielinga, P; Kuil, A; van der Heijden, I; Schuetz, JD; Borst, P Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4). Biochem J371:361-7 (2003) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| ATP-binding cassette sub-family C member 4 |
|---|
| Name: | ATP-binding cassette sub-family C member 4 |
|---|
| Synonyms: | ABCC4 | ATP-binding cassette sub-family C member 4 | MOAT-B | MOATB | MRP/cMOAT-related ABC transporter | MRP4 | MRP4_HUMAN | Multi-specific organic anion transporter B | Multidrug resistance-associated protein 4 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 149546.12 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1486828 |
|---|
| Residue: | 1325 |
|---|
| Sequence: | MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEEL
QGFWDKEVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYF
ENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALR
LSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAG
MAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLIT
NLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGA
VRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWD
KASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQ
QPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQK
ARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAA
SQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVW
SQQSSRPSLKDGALESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILL
NTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGI
ARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTF
LDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPV
FSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFV
IIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLE
KEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAG
KSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNE
HTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILII
DEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYV
LLQNKESLFYKMVQQLGKAEAAALTETAKQVYFKRNYPHIGHTDHMVTNTSNGQPSTLTI
FETAL
|
|
|
|---|
| BDBM50366524 |
|---|
| n/a |
|---|
| Name | BDBM50366524 |
|---|
| Synonyms: | ESTRONE | ESTROPIPATE | Estrone 3-sulfate | Estrone Sulphate |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H22O5S |
|---|
| Mol. Mass. | 350.429 |
|---|
| SMILES | C[C@]12CC[C@H]3[C@@H](CCc4cc(OS(O)(=O)=O)ccc34)[C@@H]1CCC2=O |
|---|
| Structure | 
|
|---|
Search and Browse
