| Reaction Details |
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 | Report a problem with these data |
| Target | Casein kinase I isoform alpha |
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| Ligand | BDBM50263829 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_842102 (CHEMBL2091519) |
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| IC50 | 1000±n/a nM |
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| Citation |  Yang, LL; Li, GB; Yan, HX; Sun, QZ; Ma, S; Ji, P; Wang, ZR; Feng, S; Zou, J; Yang, SY Discovery of N6-phenyl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamine derivatives as novel CK1 inhibitors using common-feature pharmacophore model based virtual screening and hit-to-lead optimization. Eur J Med Chem56:30-38 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Casein kinase I isoform alpha |
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| Name: | Casein kinase I isoform alpha |
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| Synonyms: | CK1 | CKI-alpha | CSNK1A1 | Casein Kinase I | Casein kinase 1 alpha (CK1 alpha) | Casein kinase I isoform alpha/delta | KC1A_HUMAN |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 38936.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P48729 |
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| Residue: | 337 |
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| Sequence: | MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYE
SKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM
ISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKN
LTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKK
MSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTM
LKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF
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| BDBM50263829 |
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| n/a |
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| Name | BDBM50263829 |
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| Synonyms: | 3-(2,4,6-Trimethoxybenzylidene)indolin-2-one | 3-[(2,4,6-TRIMETHOXY-PHENYL)-METHYLENE]-INDOLIN-2-ONE | 3-[(2,4,6-trimethoxyphenyl)methylidenyl]-indolin-2-one | CHEMBL489156 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H17NO4 |
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| Mol. Mass. | 311.3319 |
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| SMILES | COc1cc(OC)c(\C=C2\C(=O)Nc3ccccc23)c(OC)c1 |
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| Structure | 
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