| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Casein kinase I isoform alpha |
|---|
| Ligand | BDBM50229971 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_842102 (CHEMBL2091519) |
|---|
| IC50 | 300±n/a nM |
|---|
| Citation |  Yang, LL; Li, GB; Yan, HX; Sun, QZ; Ma, S; Ji, P; Wang, ZR; Feng, S; Zou, J; Yang, SY Discovery of N6-phenyl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamine derivatives as novel CK1 inhibitors using common-feature pharmacophore model based virtual screening and hit-to-lead optimization. Eur J Med Chem56:30-38 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Casein kinase I isoform alpha |
|---|
| Name: | Casein kinase I isoform alpha |
|---|
| Synonyms: | CK1 | CKI-alpha | CSNK1A1 | Casein Kinase I | Casein kinase 1 alpha (CK1 alpha) | Casein kinase I isoform alpha/delta | KC1A_HUMAN |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 38936.59 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P48729 |
|---|
| Residue: | 337 |
|---|
| Sequence: | MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYE
SKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM
ISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKN
LTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKK
MSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTM
LKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF
|
|
|
|---|
| BDBM50229971 |
|---|
| n/a |
|---|
| Name | BDBM50229971 |
|---|
| Synonyms: | 4-(4-(2,3-Dihydrobenzo[1,4]dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl)benzamide | 4-(4-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide | 4-[4-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide | CHEMBL410456 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H18N4O3 |
|---|
| Mol. Mass. | 398.414 |
|---|
| SMILES | NC(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc2OCCOc2c1)-c1ccccn1 |
|---|
| Structure | 
|
|---|
Search and Browse
