| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 |
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| Ligand | BDBM50420304 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_839770 (CHEMBL2089692) |
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| IC50 | 26±n/a nM |
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| Citation |  Cho, YS; Angove, H; Brain, C; Chen, CH; Cheng, H; Cheng, R; Chopra, R; Chung, K; Congreve, M; Dagostin, C; Davis, DJ; Feltell, R; Giraldes, J; Hiscock, SD; Kim, S; Kovats, S; Lagu, B; Lewry, K; Loo, A; Lu, Y; Luzzio, M; Maniara, W; McMenamin, R; Mortenson, PN; Benning, R; Rees, DC; Shen, J; Smith, T; Wang, Y; Williams, G; Woolford, AJ; Wrona, W; Xu, M; Yang, F; Howard, S Fragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 Inhibitors. ACS Med Chem Lett3:445-449 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 |
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| Name: | Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 |
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| Synonyms: | CDK6/CycD3 | CDK6/D3 | CDK6/G1/S-specific cyclin D3 | CDK6/cyclin D3 | Cyclin-dependent kinase 6 | Cyclin-dependent kinase 6/G1/S-specific cyclin D3 |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Cyclin-dependent kinase 6 |
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| Synonyms: | CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 36937.42 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q00534 |
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| Residue: | 326 |
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| Sequence: | MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR
EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE
TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV
VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE
EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
QDLERCKENLDSHLPPSQNTSELNTA
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| Component 2 |
| Name: | G1/S-specific cyclin-D3 |
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| Synonyms: | CCND3 | CCND3_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 32521.90 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30281 |
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| Residue: | 292 |
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| Sequence: | MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKML
AYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLT
IEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKK
HAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCL
RACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL
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| BDBM50420304 |
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| n/a |
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| Name | BDBM50420304 |
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| Synonyms: | CHEMBL2089065 | US8598217, 165 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H27N7O |
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| Mol. Mass. | 501.5817 |
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| SMILES | CN(C)C1CCN(CC1)c1ccc2[nH]c(nc2n1)C(=O)c1ccc(C#N)c(c1)-c1cncc2ccccc12 |
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| Structure | 
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