| Reaction Details |
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 | Report a problem with these data |
| Target | 40S ribosomal protein S27 |
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| Ligand | BDBM15912 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_840521 (CHEMBL2089872) |
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| IC50 | 529±n/a nM |
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| Citation |  Kusakabe, K; Ide, N; Daigo, Y; Itoh, T; Higashino, K; Okano, Y; Tadano, G; Tachibana, Y; Sato, Y; Inoue, M; Wada, T; Iguchi, M; Kanazawa, T; Ishioka, Y; Dohi, K; Tagashira, S; Kido, Y; Sakamoto, S; Yasuo, K; Maeda, M; Yamamoto, T; Higaki, M; Endoh, T; Ueda, K; Shiota, T; Murai, H; Nakamura, Y Diaminopyridine-based potent and selective mps1 kinase inhibitors binding to an unusual flipped-Peptide conformation. ACS Med Chem Lett3:560-564 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 40S ribosomal protein S27 |
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| Name: | 40S ribosomal protein S27 |
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| Synonyms: | MPS-1 | MPS1 | Metallopan-stimulin 1 | RPS27 | RS27_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 9472.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1446775 |
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| Residue: | 84 |
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| Sequence: | MPLAKDLLHPSPEEEKRKHKKKRLVQSPNSYFMDVKCPGCYKITTVFSHAQTVVLCVGCS
TVLCQPTGGKARLTEGCSFRRKQH
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| BDBM15912 |
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| n/a |
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| Name | BDBM15912 |
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| Synonyms: | 2-pyridinecarboxamide deriv. 8b | 4-Amino-5-cyano-6-ethoxy-pyridine-2-carboxylic acid benzylamide | 4-amino-N-benzyl-5-cyano-6-ethoxypyridine-2-carboxamide |
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| Type | Small organic molecule |
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| Emp. Form. | C16H16N4O2 |
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| Mol. Mass. | 296.3238 |
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| SMILES | CCOc1nc(cc(N)c1C#N)C(=O)NCc1ccccc1 |
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| Structure | 
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