Reaction Details |
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Target | Protein-glutamine gamma-glutamyltransferase K |
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Ligand | BDBM50420474 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_841032 (CHEMBL2091158) |
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IC50 | 18±n/a nM |
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Citation | Prime, ME; Andersen, OA; Barker, JJ; Brooks, MA; Cheng, RK; Toogood-Johnson, I; Courtney, SM; Brookfield, FA; Yarnold, CJ; Marston, RW; Johnson, PD; Johnsen, SF; Palfrey, JJ; Vaidya, D; Erfan, S; Ichihara, O; Felicetti, B; Palan, S; Pedret-Dunn, A; Schaertl, S; Sternberger, I; Ebneth, A; Scheel, A; Winkler, D; Toledo-Sherman, L; Beconi, M; Macdonald, D; Muñoz-Sanjuan, I; Dominguez, C; Wityak, J Discovery and structure-activity relationship of potent and selective covalent inhibitors of transglutaminase 2 for Huntington's disease. J Med Chem55:1021-46 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Protein-glutamine gamma-glutamyltransferase K |
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Name: | Protein-glutamine gamma-glutamyltransferase K |
Synonyms: | KTG | Protein-glutamine gamma-glutamyltransferase K | TGM1 | TGM1_HUMAN | Transglutaminase-1 (TG1) |
Type: | Protein |
Mol. Mass.: | 89778.63 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 817 |
Sequence: | MMDGPRSDVGRWGGNPLQPPTTPSPEPEPEPDGRSRRGGGRSFWARCCGCCSCRNAADDD
WGPEPSDSRGRGSSSGTRRPGSRGSDSRRPVSRGSGVNAAGDGTIREGMLVVNGVDLLSS
RSDQNRREHHTDEYEYDELIVRRGQPFHMLLLLSRTYESSDRITLELLIGNNPEVGKGTH
VIIPVGKGGSGGWKAQVVKASGQNLNLRVHTSPNAIIGKFQFTVRTQSDAGEFQLPFDPR
NEIYILFNPWCPEDIVYVDHEDWRQEYVLNESGRIYYGTEAQIGERTWNYGQFDHGVLDA
CLYILDRRGMPYGGRGDPVNVSRVISAMVNSLDDNGVLIGNWSGDYSRGTNPSAWVGSVE
ILLSYLRTGYSVPYGQCWVFAGVTTTVLRCLGLATRTVTNFNSAHDTDTSLTMDIYFDEN
MKPLEHLNHDSVWNFHVWNDCWMKRPDLPSGFDGWQVVDATPQETSSGIFCCGPCSVESI
KNGLVYMKYDTPFIFAEVNSDKVYWQRQDDGSFKIVYVEEKAIGTLIVTKAISSNMREDI
TYLYKHPEGSDAERKAVETAAAHGSKPNVYANRGSAEDVAMQVEAQDAVMGQDLMVSVML
INHSSSRRTVKLHLYLSVTFYTGVSGTIFKETKKEVELAPGASDRVTMPVAYKEYRPHLV
DQGAMLLNVSGHVKESGQVLAKQHTFRLRTPDLSLTLLGAAVVGQECEVQIVFKNPLPVT
LTNVVFRLEGSGLQRPKILNVGDIGGNETVTLRQSFVPVRPGPRQLIASLDSPQLSQVHG
VIQVDVAPAPGDGGFFSDAGGDSHLGETIPMASRGGA
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BDBM50420474 |
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n/a |
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Name | BDBM50420474 |
Synonyms: | CHEMBL2086889 | US9073941, 607 |
Type | Small organic molecule |
Emp. Form. | C15H15N5O3 |
Mol. Mass. | 313.3113 |
SMILES | CCn1nc(nc2c1nc(=O)n(C)c2=O)-c1ccc(OC)cc1 |
Structure |
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