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TargetProtein-glutamine gamma-glutamyltransferase E
LigandBDBM50420475
Substrate/Competitorn/a
Meas. Tech.ChEMBL_841033 (CHEMBL2091159)
IC50>80000±n/a nM
Citation Prime, MEAndersen, OABarker, JJBrooks, MACheng, RKToogood-Johnson, ICourtney, SMBrookfield, FAYarnold, CJMarston, RWJohnson, PDJohnsen, SFPalfrey, JJVaidya, DErfan, SIchihara, OFelicetti, BPalan, SPedret-Dunn, ASchaertl, SSternberger, IEbneth, AScheel, AWinkler, DToledo-Sherman, LBeconi, MMacdonald, DMuñoz-Sanjuan, IDominguez, CWityak, J Discovery and structure-activity relationship of potent and selective covalent inhibitors of transglutaminase 2 for Huntington's disease. J Med Chem55:1021-46 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Protein-glutamine gamma-glutamyltransferase E
Name:Protein-glutamine gamma-glutamyltransferase E
Synonyms:Protein-glutamine glutamyltransferase E | TGM3 | TGM3_HUMAN | Transglutaminase-3 (TG3)
Type:Protein
Mol. Mass.:76625.90
Organism:Homo sapiens (Human)
Description:n/a
Residue:693
Sequence:
MAALGVQSINWQTAFNRQAHHTDKFSSQELILRRGQNFQVLMIMNKGLGSNERLEFIVST
GPYPSESAMTKAVFPLSNGSSGGWSAVLQASNGNTLTISISSPASAPIGRYTMALQIFSQ
GGISSVKLGTFILLFNPWLNVDSVFMGNHAEREEYVQEDAGIIFVGSTNRIGMIGWNFGQ
FEEDILSICLSILDRSLNFRRDAATDVASRNDPKYVGRVLSAMINSNDDNGVLAGNWSGT
YTGGRDPRSWNGSVEILKNWKKSGFSPVRYGQCWVFAGTLNTALRSLGIPSRVITNFNSA
HDTDRNLSVDVYYDPMGNPLDKGSDSVWNFHVWNEGWFVRSDLGPSYGGWQVLDATPQER
SQGVFQCGPASVIGVREGDVQLNFDMPFIFAEVNADRITWLYDNTTGKQWKNSVNSHTIG
RYISTKAVGSNARMDVTDKYKYPEGSDQERQVFQKALGKLKPNTPFAATSSMGLETEEQE
PSIIGKLKVAGMLAVGKEVNLVLLLKNLSRDTKTVTVNMTAWTIIYNGTLVHEVWKDSAT
MSLDPEEEAEHPIKISYAQYEKYLKSDNMIRITAVCKVPDESEVVVERDIILDNPTLTLE
VLNEARVRKPVNVQMLFSNPLDEPVRDCVLMVEGSGLLLGNLKIDVPTLGPKEGSRVRFD
ILPSRSGTKQLLADFSCNKFPAIKAMLSIDVAE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50420475
n/a
NameBDBM50420475
Synonyms:CHEMBL2089396
TypeSmall organic molecule
Emp. Form.C23H27N3O5S
Mol. Mass.457.543
SMILESC=CC(=O)Nc1ccc(cc1)S(=O)(=O)N1CCC(CNC(=O)OCc2ccccc2)CC1
Structure
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