Reaction Details |
| Report a problem with these data |
Target | Coagulation factor XIII A chain |
---|
Ligand | BDBM50420478 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_841034 (CHEMBL2091160) |
---|
IC50 | 350±n/a nM |
---|
Citation | Prime, ME; Andersen, OA; Barker, JJ; Brooks, MA; Cheng, RK; Toogood-Johnson, I; Courtney, SM; Brookfield, FA; Yarnold, CJ; Marston, RW; Johnson, PD; Johnsen, SF; Palfrey, JJ; Vaidya, D; Erfan, S; Ichihara, O; Felicetti, B; Palan, S; Pedret-Dunn, A; Schaertl, S; Sternberger, I; Ebneth, A; Scheel, A; Winkler, D; Toledo-Sherman, L; Beconi, M; Macdonald, D; Muñoz-Sanjuan, I; Dominguez, C; Wityak, J Discovery and structure-activity relationship of potent and selective covalent inhibitors of transglutaminase 2 for Huntington's disease. J Med Chem55:1021-46 (2012) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Coagulation factor XIII A chain |
---|
Name: | Coagulation factor XIII A chain |
Synonyms: | Coagulation factor XIII | F13A | F13A1 | F13A_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 83261.29 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1475048 |
Residue: | 732 |
Sequence: | MSETSRTAFGGRRAVPPNNSNAAEDDLPTVELQGVVPRGVNLQEFLNVTSVHLFKERWDT
NKVDHHTDKYENNKLIVRRGQSFYVQIDFSRPYDPRRDLFRVEYVIGRYPQENKGTYIPV
PIVSELQSGKWGAKIVMREDRSVRLSIQSSPKCIVGKFRMYVAVWTPYGVLRTSRNPETD
TYILFNPWCEDDAVYLDNEKEREEYVLNDIGVIFYGEVNDIKTRSWSYGQFEDGILDTCL
YVMDRAQMDLSGRGNPIKVSRVGSAMVNAKDDEGVLVGSWDNIYAYGVPPSAWTGSVDIL
LEYRSSENPVRYGQCWVFAGVFNTFLRCLGIPARIVTNYFSAHDNDANLQMDIFLEEDGN
VNSKLTKDSVWNYHCWNEAWMTRPDLPVGFGGWQAVDSTPQENSDGMYRCGPASVQAIKH
GHVCFQFDAPFVFAEVNSDLIYITAKKDGTHVVENVDATHIGKLIVTKQIGGDGMMDITD
TYKFQEGQEEERLALETALMYGAKKPLNTEGVMKSRSNVDMDFEVENAVLGKDFKLSITF
RNNSHNRYTITAYLSANITFYTGVPKAEFKKETFDVTLEPLSFKKEAVLIQAGEYMGQLL
EQASLHFFVTARINETRDVLAKQKSTVLTIPEIIIKVRGTQVVGSDMTVTVQFTNPLKET
LRNVWVHLDGPGVTRPMKKMFREIRPNSTVQWEEVCRPWVSGHRKLIASMSSDSLRHVYG
ELDVQIQRRPSM
|
|
|
BDBM50420478 |
---|
n/a |
---|
Name | BDBM50420478 |
Synonyms: | CHEMBL2086479 |
Type | Small organic molecule |
Emp. Form. | C21H23N3O5S |
Mol. Mass. | 429.489 |
SMILES | C=CC(=O)Nc1cccc(c1)S(=O)(=O)N1CCN(CC1)C(=O)OCc1ccccc1 |
Structure |
|