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TargetCoagulation factor XIII
LigandBDBM50420506
Substrate/Competitorn/a
Meas. Tech.ChEMBL_841034
IC50 340±n/a nM
Citation Prime MEAndersen OABarker JJBrooks MACheng RKToogood-Johnson ICourtney SMBrookfield FAYarnold CJMarston RWJohnson PDJohnsen SFPalfrey JJVaidya DErfan SIchihara OFelicetti BPalan SPedret-Dunn ASchaertl SSternberger IEbneth AScheel AWinkler DToledo-Sherman LBeconi MMacdonald DMuñoz-Sanjuan IDominguez CWityak J Discovery and structure-activity relationship of potent and selective covalent inhibitors of transglutaminase 2 for Huntington's disease. J Med Chem 55:1021-46 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor XIII
Name:Coagulation factor XIII
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:83261.29
Organism:Homo sapiens (Human)
Description:ChEMBL_1475048
Residue:732
Sequence:
MSETSRTAFGGRRAVPPNNSNAAEDDLPTVELQGVVPRGVNLQEFLNVTSVHLFKERWDT
NKVDHHTDKYENNKLIVRRGQSFYVQIDFSRPYDPRRDLFRVEYVIGRYPQENKGTYIPV
PIVSELQSGKWGAKIVMREDRSVRLSIQSSPKCIVGKFRMYVAVWTPYGVLRTSRNPETD
TYILFNPWCEDDAVYLDNEKEREEYVLNDIGVIFYGEVNDIKTRSWSYGQFEDGILDTCL
YVMDRAQMDLSGRGNPIKVSRVGSAMVNAKDDEGVLVGSWDNIYAYGVPPSAWTGSVDIL
LEYRSSENPVRYGQCWVFAGVFNTFLRCLGIPARIVTNYFSAHDNDANLQMDIFLEEDGN
VNSKLTKDSVWNYHCWNEAWMTRPDLPVGFGGWQAVDSTPQENSDGMYRCGPASVQAIKH
GHVCFQFDAPFVFAEVNSDLIYITAKKDGTHVVENVDATHIGKLIVTKQIGGDGMMDITD
TYKFQEGQEEERLALETALMYGAKKPLNTEGVMKSRSNVDMDFEVENAVLGKDFKLSITF
RNNSHNRYTITAYLSANITFYTGVPKAEFKKETFDVTLEPLSFKKEAVLIQAGEYMGQLL
EQASLHFFVTARINETRDVLAKQKSTVLTIPEIIIKVRGTQVVGSDMTVTVQFTNPLKET
LRNVWVHLDGPGVTRPMKKMFREIRPNSTVQWEEVCRPWVSGHRKLIASMSSDSLRHVYG
ELDVQIQRRPSM
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BDBM50420506
n/a
NameBDBM50420506
Synonyms:CHEMBL2086510
TypeSmall organic molecule
Emp. Form.C22H22F3N3O5S
Mol. Mass.497.487
SMILESFC(F)(F)c1ccccc1COC(=O)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)C=C)cc1
Structure
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