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TargetProtein-glutamine gamma-glutamyltransferase 2
LigandBDBM50420474
Substrate/Competitorn/a
Meas. Tech.ChEMBL_841030 (CHEMBL2091156)
IC50 25±n/a nM
Citation Prime, MEAndersen, OABarker, JJBrooks, MACheng, RKToogood-Johnson, ICourtney, SMBrookfield, FAYarnold, CJMarston, RWJohnson, PDJohnsen, SFPalfrey, JJVaidya, DErfan, SIchihara, OFelicetti, BPalan, SPedret-Dunn, ASchaertl, SSternberger, IEbneth, AScheel, AWinkler, DToledo-Sherman, LBeconi, MMacdonald, DMuñoz-Sanjuan, IDominguez, CWityak, J Discovery and structure-activity relationship of potent and selective covalent inhibitors of transglutaminase 2 for Huntington's disease. J Med Chem55:1021-46 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Protein-glutamine gamma-glutamyltransferase 2
Name:Protein-glutamine gamma-glutamyltransferase 2
Synonyms:Protein-glutamine gamma-glutamyltransferase | Protein-glutamine gamma-glutamyltransferase 2 (TG2) | TGM2 | TGM2_HUMAN | Tissue transglutaminase | Tissue transglutaminase (TG2) | Transglutaminase 2 (TGM2) | Transglutaminase C | Transglutaminase-2
Type:Protein
Mol. Mass.:77309.30
Organism:Homo sapiens (Human)
Description:P21980
Residue:687
Sequence:
MAEELVLERCDLELETNGRDHHTADLCREKLVVRRGQPFWLTLHFEGRNYEASVDSLTFS
VVTGPAPSQEAGTKARFPLRDAVEEGDWTATVVDQQDCTLSLQLTTPANAPIGLYRLSLE
ASTGYQGSSFVLGHFILLFNAWCPADAVYLDSEEERQEYVLTQQGFIYQGSAKFIKNIPW
NFGQFEDGILDICLILLDVNPKFLKNAGRDCSRRSSPVYVGRVVSGMVNCNDDQGVLLGR
WDNNYGDGVSPMSWIGSVDILRRWKNHGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTN
YNSAHDQNSNLLIEYFRNEFGEIQGDKSEMIWNFHCWVESWMTRPDLQPGYEGWQALDPT
PQEKSEGTYCCGPVPVRAIKEGDLSTKYDAPFVFAEVNADVVDWIQQDDGSVHKSINRSL
IVGLKISTKSVGRDEREDITHTYKYPEGSSEEREAFTRANHLNKLAEKEETGMAMRIRVG
QSMNMGSDFDVFAHITNNTAEEYVCRLLLCARTVSYNGILGPECGTKYLLNLNLEPFSEK
SVPLCILYEKYRDCLTESNLIKVRALLVEPVINSYLLAERDLYLENPEIKIRILGEPKQK
RKLVAEVSLQNPLPVALEGCTFTVEGAGLTEEQKTVEIPDPVEAGEEVKVRMDLLPLHMG
LHKLVVNFESDKLKAVKGFRNVIIGPA
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  Blast E-value cutoff:
BDBM50420474
n/a
NameBDBM50420474
Synonyms:CHEMBL2086889 | US9073941, 607
TypeSmall organic molecule
Emp. Form.C15H15N5O3
Mol. Mass.313.3113
SMILESCCn1nc(nc2c1nc(=O)n(C)c2=O)-c1ccc(OC)cc1
Structure
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