Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetTranslocator protein
LigandBDBM50421115
Substrate/Competitorn/a
Meas. Tech.ChEMBL_842489 (CHEMBL2092214)
Ki 0.33±n/a nM
Citation Fukaya, TKodo, TIshiyama, TKakuyama, HNishikawa, HBaba, SMasumoto, S Design, synthesis and structure-activity relationships of novel benzoxazolone derivatives as 18 kDa translocator protein (TSPO) ligands. Bioorg Med Chem20:5568-82 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Translocator protein
Name:Translocator protein
Synonyms:Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:Mitochondrion membrane protein
Mol. Mass.:18945.84
Organism:Rattus norvegicus (rat)
Description:Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50421115
n/a
NameBDBM50421115
Synonyms:CHEMBL2088373
TypeSmall organic molecule
Emp. Form.C23H20N2O4
Mol. Mass.388.4159
SMILESCOc1cccc(c1)-c1ccc2oc(=O)n(CC(=O)N(C)c3ccccc3)c2c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: