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TargetTranslocator protein
LigandBDBM50421118
Substrate/Competitorn/a
Meas. Tech.ChEMBL_842489 (CHEMBL2092214)
Ki 0.68±n/a nM
Citation Fukaya, TKodo, TIshiyama, TKakuyama, HNishikawa, HBaba, SMasumoto, S Design, synthesis and structure-activity relationships of novel benzoxazolone derivatives as 18 kDa translocator protein (TSPO) ligands. Bioorg Med Chem20:5568-82 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Translocator protein
Name:Translocator protein
Synonyms:Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:Mitochondrion membrane protein
Mol. Mass.:18945.84
Organism:Rattus norvegicus (rat)
Description:Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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  Blast E-value cutoff:
BDBM50421118
n/a
NameBDBM50421118
Synonyms:CHEMBL2088376
TypeSmall organic molecule
Emp. Form.C23H17F3N2O3
Mol. Mass.426.3879
SMILESCN(C(=O)Cn1c2cc(ccc2oc1=O)-c1ccc(cc1)C(F)(F)F)c1ccccc1
Structure
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