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TargetMAP kinase p38 beta
LigandBDBM50317588
Substrate/Competitorn/a
Meas. Tech.ChEMBL_839530
IC50 15.8±n/a nM
Citation Tynebor RMChen MHNatarajan SRO'Neill EAThompson JEFitzgerald CEO'Keefe SJDoherty JB Synthesis and biological activity of pyridopyridazin-6-one p38a MAP kinase inhibitors. Part 2. Bioorg Med Chem Lett 22:5979-83 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
MAP kinase p38 beta
Name:MAP Kinase p38 beta
Synonyms:Mitogen-activated protein kinase 11 | Mitogen-activated protein kinase p38 beta | p38B
Type:Enzyme
Mol. Mass.:41390.66
Organism:Mus musculus (mouse)
Description:Q9WUI1
Residue:364
Sequence:
MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ
SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ
ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGNDYIDQLKRIMEVVG
TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSVFHGANPLAIDLLGRMLVLDSDQRVSAA
EALAHAYFSQYHDPDDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPLEPSQLPGTH
EIEQ
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  Blast E-value cutoff:
BDBM50317588
n/a
NameBDBM50317588
Synonyms:6-(2,4-difluorophenyl)-1-(2-fluoro-5-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)-2H-quinolizin-2-one | CHEMBL1096192
TypeSmall organic molecule
Emp. Form.C24H14F3N3O2
Mol. Mass.433.3821
SMILESCc1nnc(o1)-c1ccc(F)c(c1)-c1c2cccc(-c3ccc(F)cc3F)n2ccc1=O |(31.09,6.57,;30.64,5.09,;31.57,3.86,;30.68,2.6,;29.21,3.05,;29.18,4.59,;27.88,2.28,;26.54,3.06,;25.2,2.28,;25.21,.74,;23.87,-.03,;26.54,-.02,;27.87,.74,;26.54,-1.56,;27.87,-2.34,;29.19,-1.58,;30.52,-2.34,;30.52,-3.88,;29.19,-4.65,;29.19,-6.19,;27.85,-6.96,;27.85,-8.5,;29.19,-9.27,;29.19,-10.81,;30.53,-8.49,;30.52,-6.95,;31.85,-6.18,;27.86,-3.88,;26.54,-4.65,;25.21,-3.88,;25.21,-2.34,;23.87,-1.58,)|
Structure
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