Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetMAP kinase p38 beta
LigandBDBM50421133
Substrate/Competitorn/a
Meas. Tech.ChEMBL_839530
IC50 36±n/a nM
Citation Tynebor RMChen MHNatarajan SRO'Neill EAThompson JEFitzgerald CEO'Keefe SJDoherty JB Synthesis and biological activity of pyridopyridazin-6-one p38a MAP kinase inhibitors. Part 2. Bioorg Med Chem Lett 22:5979-83 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
MAP kinase p38 beta
Name:MAP Kinase p38 beta
Synonyms:Mitogen-activated protein kinase 11 | Mitogen-activated protein kinase p38 beta | p38B
Type:Enzyme
Mol. Mass.:41390.66
Organism:Mus musculus (mouse)
Description:Q9WUI1
Residue:364
Sequence:
MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ
SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ
ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGNDYIDQLKRIMEVVG
TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSVFHGANPLAIDLLGRMLVLDSDQRVSAA
EALAHAYFSQYHDPDDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPLEPSQLPGTH
EIEQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50421133
n/a
NameBDBM50421133
Synonyms:CHEMBL2088575
TypeSmall organic molecule
Emp. Form.C26H19F2N3O3
Mol. Mass.459.4442
SMILESFc1ccc(Oc2ccc3c(-c4cc(ccc4C=C)C(=O)NC4CC4)c(=O)ccn3n2)c(F)c1 |(13.19,-41.38,;13.18,-39.84,;11.85,-39.08,;11.84,-37.54,;13.17,-36.77,;13.17,-35.23,;11.83,-34.46,;11.82,-32.92,;10.5,-32.17,;9.18,-32.93,;7.85,-32.17,;7.85,-30.63,;9.18,-29.86,;9.18,-28.31,;7.84,-27.55,;6.52,-28.32,;6.51,-29.86,;5.18,-30.63,;3.85,-29.86,;10.51,-27.54,;10.5,-26,;11.85,-28.3,;13.18,-27.53,;14.72,-27.52,;13.94,-26.19,;6.51,-32.94,;5.18,-32.17,;6.51,-34.48,;7.85,-35.25,;9.18,-34.47,;10.51,-35.23,;14.51,-37.52,;15.84,-36.75,;14.52,-39.06,)|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: