| Reaction Details |
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 | Report a problem with these data |
| Target | GTPase HRas |
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| Ligand | BDBM50421182 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_839703 (CHEMBL2089530) |
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| Kd | 28000±n/a nM |
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| Citation |  Wang, W; Fang, G; Rudolph, J Ras inhibition via direct Ras binding--is there a path forward? Bioorg Med Chem Lett22:5766-76 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| GTPase HRas |
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| Name: | GTPase HRas |
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| Synonyms: | GTPase HRas, N-terminally processed | H-Ras | H-Ras-1 | HRAS | HRAS1 | Ha-Ras | His6-Ha-Ras-CVLS | RASH_HUMAN | Transforming protein p21 | Transforming protein p21/H-Ras-1 | Wild-type Ha-Ras | c-H-ras | p21ras |
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| Type: | Other Protein Type |
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| Mol. Mass.: | 21293.37 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P01112 |
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| Residue: | 189 |
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| Sequence: | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL
AARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPG
CMSCKCVLS
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| BDBM50421182 |
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| n/a |
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| Name | BDBM50421182 |
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| Synonyms: | CHEMBL2086797 |
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| Type | Small organic molecule |
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| Emp. Form. | C92H142N22O27 |
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| Mol. Mass. | 1988.2431 |
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| SMILES | CC[C@H](C)[C@H](NC(=O)CN1C\C=C/CCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(O)=O)C1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(N)=O |r,c:11| |
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| Structure | 
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