| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin B-like cysteine protease |
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| Ligand | BDBM50412201 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_840092 (CHEMBL2090696) |
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| IC50 | 64000±n/a nM |
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| Citation |  Lavrado, J; Mackey, Z; Hansell, E; McKerrow, JH; Paulo, A; Moreira, R Antitrypanosomal and cysteine protease inhibitory activities of alkyldiamine cryptolepine derivatives. Bioorg Med Chem Lett22:6256-60 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin B-like cysteine protease |
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| Name: | Cathepsin B-like cysteine protease |
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| Synonyms: | CPC | Cathepsin B-Like Cysteine Protease (TbcatB) | Cysteine peptidase C | TbcatB |
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| Type: | Enzyme |
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| Mol. Mass.: | 37220.37 |
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| Organism: | Trypanosoma brucei |
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| Description: | Enzyme was expressed in yeast Pichia pastoris. |
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| Residue: | 340 |
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| Sequence: | MHLMRACITFCIASTAVVAVNAALVAEDAPVLSKAFVDRVNRLNRGIWKAKYDGVMQNIT
LREAKRLNGVIKKNNNASILPKRRFTEEEARAPLPSSFDSAEAWPNCPTIPQIADQSACG
SCWAVAAASAMSDRFCTMGGVQDVHISAGDLLACCSDCGDGCNGGDPDRAWAYFSSTGLV
SDYCQPYPFPHCSHHSKSKNGYPPCSQFNFDTPKCNYTCDDPTIPVVNYRSWTSYALQGE
DDYMRELFFRGPFEVAFDVYEDFIAYNSGVYHHVSGQYLGGHAVRLVGWGTSNGVPYWKI
ANSWNTEWGMDGYFLIRRGSSECGIEDGGSAGIPLAPNTA
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| BDBM50412201 |
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| n/a |
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| Name | BDBM50412201 |
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| Synonyms: | CRYPTOLEPINE HYDROCHLORIDE | Cryptolepine |
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| Type | Small organic molecule |
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| Emp. Form. | C16H12N2 |
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| Mol. Mass. | 232.2799 |
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| SMILES | Cn1c2c(cc3ccccc13)nc1ccccc21 |
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| Structure | 
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