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TargetSigma non-opioid intracellular receptor 1
LigandBDBM50170657
Substrate/Competitorn/a
Meas. Tech.ChEBML_201732
IC50 1.2±n/a nM
Citation Chambers, MSBaker, RBillington, DCKnight, AKMiddlemiss, DNWong, EH Spiropiperidines as high-affinity, selective sigma ligands. J Med Chem35:2033-9 (1992) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Sigma non-opioid intracellular receptor 1
Name:Sigma non-opioid intracellular receptor 1
Synonyms:Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:Enzyme Catalytic Domain
Mol. Mass.:25124.85
Organism:Homo sapiens (Human)
Description:Q99720
Residue:223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
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  Blast E-value cutoff:
BDBM50170657
n/a
NameBDBM50170657
Synonyms:1''-butyl-3,4-dihydro-2H-spiro[naphthalene-1,4''-piperidine] | 1'-butyl-3,4-dihydro-2H-spiro[naphthalene-1,4'-piperidine]; HCl | CHEMBL1788381 | CHEMBL62540
TypeSmall organic molecule
Emp. Form.C18H27N
Mol. Mass.257.4137
SMILESCCCCN1CCC2(CCCc3ccccc23)CC1
Structure
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