| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase/RNaseH |
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| Ligand | BDBM1288 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_196348 (CHEMBL802044) |
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| IC50 | 457±n/a nM |
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| Citation |  Gibson, S; McGuire, R; Rees, DC Principal components describing biological activities and molecular diversity of heterocyclic aromatic ring fragments. J Med Chem39:4065-72 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Reverse transcriptase/RNaseH |
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| Name: | Reverse transcriptase/RNaseH |
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| Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH |
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| Type: | PROTEIN |
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| Mol. Mass.: | 65229.15 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_1473730 |
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| Residue: | 566 |
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| Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
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| BDBM1288 |
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| n/a |
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| Name | BDBM1288 |
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| Synonyms: | 3-Aminopyridin-2(1H)-one analogue 8 | 5-ethyl-6-methyl-3-[(naphthalen-2-ylmethyl)amino]-1,2-dihydropyridin-2-one | CHEMBL318730 | Pyridinone deriv. 10 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H20N2O |
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| Mol. Mass. | 292.3749 |
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| SMILES | CCc1cc(NCc2ccc3ccccc3c2)c(=O)[nH]c1C |
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| Structure | 
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