Reaction Details |
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Target | Farnesyl pyrophosphate synthase |
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Ligand | BDBM50138041 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_194806 (CHEMBL799889) |
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IC50 | 4.0±n/a nM |
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Citation | Kotsikorou, E; Oldfield, E A quantitative structure-activity relationship and pharmacophore modeling investigation of aryl-X and heterocyclic bisphosphonates as bone resorption agents. J Med Chem46:2932-44 (2003) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Farnesyl pyrophosphate synthase |
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Name: | Farnesyl pyrophosphate synthase |
Synonyms: | Dimethylallyltranstransferase | FDPS | FPP synthase | FPP synthetase | FPPS_HUMAN | FPS | Farnesyl diphosphate synthase | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | KIAA1293 | P14324 |
Type: | Enzyme |
Mol. Mass.: | 48272.89 |
Organism: | Homo sapiens (Human) |
Description: | P14324 |
Residue: | 419 |
Sequence: | MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRA
LCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAI
GGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRG
QICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLD
LLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLE
MGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKE
AEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
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BDBM50138041 |
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n/a |
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Name | BDBM50138041 |
Synonyms: | 1-hydroxy-3-(methyl(2-phenoxyethyl)amino)propane-1,1-diyldiphosphonic acid | CHEMBL53982 | [1-hydroxy-3-[methyl(2-phenoxyethyl)amino]propylidene-1,1-bisphosphonate | {1-hydroxy-3-[methyl-(2-phenoxy-ethyl)-amino]-1-phosphono-propyl}-phosphonic acid |
Type | Small organic molecule |
Emp. Form. | C12H21NO8P2 |
Mol. Mass. | 369.2446 |
SMILES | CN(CCOc1ccccc1)CCC(O)(P(O)(O)=O)P(O)(O)=O |
Structure |
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