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TargetTissue factor
LigandBDBM50203122
Substrate/Competitorn/a
Meas. Tech.ChEMBL_936735 (CHEMBL2319887)
IC50 8.4±n/a nM
Citation Ge, HXZhang, JChen, LKou, JPYu, BY Chemical and microbial semi-synthesis of tetrahydroprotoberberines as inhibitors on tissue factor procoagulant activity. Bioorg Med Chem21:62-9 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tissue factor
Name:Tissue factor
Synonyms:CD_antigen=CD142 | Coagulation factor III | Coagulation factor VII/tissue factor | F3 | TF | TF_HUMAN | Thromboplastin | Tissue factor
Type:PROTEIN
Mol. Mass.:33067.61
Organism:Homo sapiens (Human)
Description:ChEMBL_936735
Residue:295
Sequence:
METPAWPRVPRPETAVARTLLLGWVFAQVAGASGTTNTVAAYNLTWKSTNFKTILEWEPK
PVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGS
AGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFG
KDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVE
CMGQEKGEFREIFYIIGAVVFVVIILVIILAISLHKCRKAGVGQSWKENSPLNVS
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  Blast E-value cutoff:
BDBM50203122
n/a
NameBDBM50203122
Synonyms:5,8,13,13a-tetrahydro-9,10-dimethoxy-6H-benzo(g)-1,3-benzodioxolo(5,6-a)quinolizine | 5,8,13,13a-tetrahydro-9,10-dimethoxy-6H-benzo(g)benzo-1,3-dioxolo(5,6-a)quinolizine | 9,10-dimethoxy-2,3-(methylenedioxy)berbine | 9,10-dimethoxy-5,8,13,13a-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline | CHEMBL275097 | Canadin | canadine | tetrahydroberberine | xanthopuccine
TypeSmall organic molecule
Emp. Form.C20H21NO4
Mol. Mass.339.385
SMILESCOc1ccc2CC3N(CCc4cc5OCOc5cc34)Cc2c1OC
Structure
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