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TargetCoagulation factor VII/tissue factor
LigandBDBM50170666
Substrate/Competitorn/a
Meas. Tech.ChEMBL_936735
IC50 15±n/a nM
Citation Ge HXZhang JChen LKou JPYu BY Chemical and microbial semi-synthesis of tetrahydroprotoberberines as inhibitors on tissue factor procoagulant activity. Bioorg Med Chem 21:62-9 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor VII/tissue factor
Name:Coagulation factor VII/tissue factor
Synonyms:CD_antigen=CD142 | Coagulation factor III | TF | Thromboplastin | Tissue factor
Type:PROTEIN
Mol. Mass.:33067.61
Organism:Homo sapiens (Human)
Description:ChEMBL_936735
Residue:295
Sequence:
METPAWPRVPRPETAVARTLLLGWVFAQVAGASGTTNTVAAYNLTWKSTNFKTILEWEPK
PVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGS
AGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFG
KDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVE
CMGQEKGEFREIFYIIGAVVFVVIILVIILAISLHKCRKAGVGQSWKENSPLNVS
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  Blast E-value cutoff:
BDBM50170666
n/a
NameBDBM50170666
Synonyms:2,3,9,10-Tetramethoxy-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline | CHEMBL187892
TypeSmall organic molecule
Emp. Form.C21H25NO4
Mol. Mass.355.4275
SMILESCOc1cc2CCN3Cc4c(CC3c2cc1OC)ccc(OC)c4OC
Structure
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