| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidylate kinase |
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| Ligand | BDBM50359625 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_936739 (CHEMBL2319891) |
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| Ki | 170±n/a nM |
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| Citation |  Toti, KS; Verbeke, F; Risseeuw, MD; Frecer, V; Munier-Lehmann, H; Van Calenbergh, S Synthesis and evaluation of 5'-modified thymidines and 5-hydroxymethyl-2'-deoxyuridines as Mycobacterium tuberculosis thymidylate kinase inhibitors. Bioorg Med Chem21:257-68 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidylate kinase |
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| Name: | Thymidylate kinase |
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| Synonyms: | KTHY_MYCTU | TMPK | Thymidine monophosphate kinase | dTMP kinase | tmk |
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| Type: | PROTEIN |
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| Mol. Mass.: | 22636.29 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | ChEMBL_208218 |
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| Residue: | 214 |
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| Sequence: | MLIAIEGVDGAGKRTLVEKLSGAFRAAGRSVATLAFPRYGQSVAADIAAEALHGEHGDLA
SSVYAMATLFALDRAGAVHTIQGLCRGYDVVILDRYVASNAAYSAARLHENAAGKAAAWV
QRIEFARLGLPKPDWQVLLAVSAELAGERSRGRAQRDPGRARDNYERDAELQQRTGAVYA
ELAAQGWGGRWLVVGADVDPGRLAATLAPPDVPS
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| BDBM50359625 |
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| n/a |
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| Name | BDBM50359625 |
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| Synonyms: | CHEMBL1928435 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H18ClF3N4O3S2 |
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| Mol. Mass. | 494.939 |
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| SMILES | Cc1cn([C@@H]2C[C@H](O)[C@@H](CNC(=S)Nc3ccc(Cl)c(c3)C(F)(F)F)O2)c(=O)[nH]c1=S |r| |
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| Structure | 
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