| Reaction Details |
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 | Report a problem with these data |
| Target | Kappa-type opioid receptor |
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| Ligand | BDBM50424112 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_937281 (CHEMBL2318810) |
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| Ki | 0.625000±n/a nM |
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| Citation |  Nemoto, T; Yamamoto, N; Wada, N; Harada, Y; Tomatsu, M; Ishihara, M; Hirayama, S; Iwai, T; Fujii, H; Nagase, H The effect of 17-N substituents on the activity of the opioid¿ receptor in nalfurafine derivatives. Bioorg Med Chem Lett23:268-72 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kappa-type opioid receptor |
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| Name: | Kappa-type opioid receptor |
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| Synonyms: | Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 42744.99 |
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| Organism: | Cavia porcellus (domestic guinea pig) |
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| Description: | P41144 |
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| Residue: | 380 |
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| Sequence: | MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRV
RNTVQDPAYMRNVDGVNKPV
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| BDBM50424112 |
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| n/a |
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| Name | BDBM50424112 |
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| Synonyms: | CHEMBL2315361 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H32N2O5 |
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| Mol. Mass. | 440.532 |
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| SMILES | CCN1CC[C@H]2c3c(C[C@@H]1[C@]2(O)CCCN(C)C(=O)\C=C\c1ccoc1)ccc(O)c3O |r| |
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| Structure | 
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