| Reaction Details |
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 | Report a problem with these data |
| Target | Acetolactate synthase catalytic subunit, mitochondrial |
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| Ligand | BDBM50424590 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_934102 (CHEMBL2318855) |
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| Ki | 32±n/a nM |
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| Citation |  Lee, YT; Cui, CJ; Chow, EW; Pue, N; Lonhienne, T; Wang, JG; Fraser, JA; Guddat, LW Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase. J Med Chem56:210-9 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acetolactate synthase catalytic subunit, mitochondrial |
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| Name: | Acetolactate synthase catalytic subunit, mitochondrial |
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| Synonyms: | ILV2 | ILVB_YEAST | SMR1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 74947.98 |
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| Organism: | Saccharomyces cerevisiae |
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| Description: | ChEMBL_934102 |
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| Residue: | 687 |
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| Sequence: | MIRQSTLKNFAIKRCFQHIAYRNTPAMRSVALAQRFYSSSSRYYSASPLPASKRPEPAPS
FNVDPLEQPAEPSKLAKKLRAEPDMDTSFVGLTGGQIFNEMMSRQNVDTVFGYPGGAILP
VYDAIHNSDKFNFVLPKHEQGAGHMAEGYARASGKPGVVLVTSGPGATNVVTPMADAFAD
GIPMVVFTGQVPTSAIGTDAFQEADVVGISRSCTKWNVMVKSVEELPLRINEAFEIATSG
RPGPVLVDLPKDVTAAILRNPIPTKTTLPSNALNQLTSRAQDEFVMQSINKAADLINLAK
KPVLYVGAGILNHADGPRLLKELSDRAQIPVTTTLQGLGSFDQEDPKSLDMLGMHGCATA
NLAVQNADLIIAVGARFDDRVTGNISKFAPEARRAAAEGRGGIIHFEVSPKNINKVVQTQ
IAVEGDATTNLGKMMSKIFPVKERSEWFAQINKWKKEYPYAYMEETPGSKIKPQTVIKKL
SKVANDTGRHVIVTTGVGQHQMWAAQHWTWRNPHTFITSGGLGTMGYGLPAAIGAQVAKP
ESLVIDIDGDASFNMTLTELSSAVQAGTPVKILILNNEEQGMVTQWQSLFYEHRYSHTHQ
LNPDFIKLAEAMGLKGLRVKKQEELDAKLKEFVSTKGPVLLEVEVDKKVPVLPMVAGGSG
LDEFINFDPEVERQQTELRHKRTGGKH
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| BDBM50424590 |
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| n/a |
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| Name | BDBM50424590 |
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| Synonyms: | CHEMBL2313155 | Pyrazosulfuron Ethyl |
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| Type | Small organic molecule |
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| Emp. Form. | C14H18N6O7S |
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| Mol. Mass. | 414.394 |
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| SMILES | CCOC(=O)c1cnn(C)c1S(=O)(=O)NC(=O)Nc1nc(OC)cc(OC)n1 |
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| Structure | 
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