| Reaction Details |
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 | Report a problem with these data |
| Target | Multidrug and toxin extrusion protein 2 |
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| Ligand | BDBM36880 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_934318 (CHEMBL2320304) |
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| IC50 | 6600±n/a nM |
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| Citation |  Wittwer, MB; Zur, AA; Khuri, N; Kido, Y; Kosaka, A; Zhang, X; Morrissey, KM; Sali, A; Huang, Y; Giacomini, KM Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. J Med Chem56:781-95 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Multidrug and toxin extrusion protein 2 |
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| Name: | Multidrug and toxin extrusion protein 2 |
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| Synonyms: | Kidney-specific H(+)/organic cation antiporter | MATE-2 | MATE2 | S47A2_HUMAN | SLC47A2 | Solute carrier family 47 member 2 | hMATE-2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 65098.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_934314 |
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| Residue: | 602 |
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| Sequence: | MDSLQDTVALDHGGCCPALSRLVPRGFGTEMWTLFALSGPLFLFQVLTFMIYIVSTVFCG
HLGKVELASVTLAVAFVNVCGVSVGVGLSSACDTLMSQSFGSPNKKHVGVILQRGALVLL
LCCLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQGWL
KGQEEESPFQTPGLSILHPSHSHLSRASFHLFQKITWPQVLSGVVGNCVNGVANYALVSV
LNLGVRGSAYANIISQFAQTVFLLLYIVLKKLHLETWAGWSSQCLQDWGPFFSLAVPSML
MICVEWWAYEIGSFLMGLLSVVDLSAQAVIYEVATVTYMIPLGLSIGVCVRVGMALGAAD
TVQAKRSAVSGVLSIVGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVF
EAICCVYGGVLRGTGKQAFGAAVNAITYYIIGLPLGILLTFVVRMRIMGLWLGMLACVFL
ATAAFVAYTARLDWKLAAEEAKKHSGRQQQQRAESTATRPGPEKAVLSSVATGSSPGITL
TTYSRSECHVDFFRTPEEAHALSAPTSRLSVKQLVIRRGAALGAASATLMVGLTVRILAT
RH
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| BDBM36880 |
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| n/a |
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| Name | BDBM36880 |
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| Synonyms: | 2,2'-THIOBIS(4,6-DICHLOROPHENOL) | 2,4-dichloro-6-(3,5-dichloro-2-hydroxyphenyl)sulfanylphenol | 2,4-dichloro-6-[(3,5-dichloro-2-hydroxy-phenyl)thio]phenol | 2,4-dichloro-6-[(3,5-dichloro-2-hydroxyphenyl)thio]phenol | 2-[3,5-bis(chloranyl)-2-oxidanyl-phenyl]sulfanyl-4,6-bis(chloranyl)phenol | Bithionol | HL-3 | MLS000028403 | SMR000058374 | cid_2406 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H6Cl4O2S |
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| Mol. Mass. | 356.052 |
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| SMILES | Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O |
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| Structure | 
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