| Reaction Details |
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 | Report a problem with these data |
| Target | Solute carrier family 22 member 2 |
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| Ligand | BDBM50104435 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_934317 |
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| IC50 | 900±n/a nM |
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| Citation |  Wittwer MB; Zur AA; Khuri N; Kido Y; Kosaka A; Zhang X; Morrissey KM; Sali A; Huang Y; Giacomini KM Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. J Med Chem 56:781-95 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Solute carrier family 22 member 2 |
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| Name: | Solute carrier family 22 member 2 |
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| Synonyms: | OCT2 | Organic cation transporter 2 | SLC22A2 | hOCT2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 62591.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1484077 |
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| Residue: | 555 |
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| Sequence: | MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELS
LRCGWSPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLG
PCRDGWVYETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCL
LTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIF
YQVAYTVGLLVLAGVAYALPHWRWLQFTVSLPNFFFLLYYWCIPESPRWLISQNKNAEAM
RIIKHIAKKNGKSLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSV
LYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLA
SVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGII
TPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQRPRKNKE
KMIYLQVQKLDIPLN
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| BDBM50104435 |
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| n/a |
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| Name | BDBM50104435 |
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| Synonyms: | 4-(6-Guanidino-hexanoyloxy)-benzoic acid ethyl ester | CHEMBL87563 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H23N3O4 |
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| Mol. Mass. | 321.3715 |
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| SMILES | CCOC(=O)c1ccc(OC(=O)CCCCCNC(N)=N)cc1 |
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| Structure | 
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